14 Physiology Patterns Doctors Miss in Midlife | Dr. Jay

I have spent three decades watching the same story repeat itself in my exam room.

A patient — usually a woman in her 40s or a man in his early 50s — sits down and says, "I'm doing everything right and I still feel terrible." They hand me labs that look "normal." Their doctor told them it's just aging or stress. They leave feeling dismissed.

That moment is where my 14-archetype system was born.

These are not arbitrary categories. They are the clinically distinct hormonal and metabolic patterns I see most often in midlife patients whose conventional labs do not explain their suffering. Each pattern has its own drivers, symptoms, and treatment priorities within the LCHPMF framework.

The current canonical list is maintained on Dr. Jay Wrigley’s authoritative LCHPMF framework page. The 14 names below are the same names used by the Pattern Finder Assessment and LEO; they are educational organizing lenses, not diagnoses.

The 14 canonical physiology patterns:

1. The Stress & Nervous System Pattern

2. Insulin Resistance & Metabolic Dysfunction

3. Perimenopause / Estrogen Fluctuation

4. Andropause / Testosterone Decline

5. Thyroid & Metabolic Slowdown

6. Gut Dysfunction & Dysbiosis

7. The Autoimmune Thyroid Pattern

8. Androgen Excess & Metabolic Pattern

9. The Cellular Energy Pattern

10. Post-Menopause Hormone Depletion

11. Estrogen Dominance / Progesterone Deficiency

12. The Cortisol-Driven Pattern

13. Cardiovascular & Metabolic Risk

14. The Gut-Brain-Hormone Pattern

See the authoritative 14-pattern framework page for the current definitions.

Why These 14 Matter

Each pattern has a different treatment priority inside the LCHPMF framework. Treating insulin resistance first in a cortisol-burnout patient can make symptoms worse. Starting with progesterone support in an estrogen-dominant patient who has high insulin is often ineffective.

The free 3-minute assessment at Take the free Hormone & Metabolism Assessment was built to map your symptoms to one (or more) of these 14 patterns using the same weighted scoring I use in the office. At the end you receive a Clinical Mirror report written in my voice and immediate access to Dr. Jay Wrigley’s LEO, an educational AI guide who already knows your archetype.

If the assessment points to a pattern that benefits from targeted supplements, those recommendations link directly to drjaywrigley.com with your automatic 15% patient discount applied.

Take the Assessment

It takes 3 minutes. The pattern it reveals may explain years of unexplained symptoms.

→ Start here: assessment.drjaywrigley.com

I read every reply. Tell me which archetype it shows for you. I'm here to help you finally understand the signals your body has been sending.

— Dr. Jay Wrigley, NMD