DIMension 3® 120 Capsules

DIMension 3® — Dr. Jay Wrigley's Estrogen Metabolism and Detoxification Protocol

DIMension 3® is a cornerstone of Dr. Jay Wrigley's Estrogen Dominant protocol — one of the most common hormonal patterns he identifies in both women and men over 40. As an NMD and Functional Medicine Doctor, Dr. Wrigley has observed that estrogen dominance is rarely about having too much estrogen in absolute terms. More commonly, it reflects an imbalance in estrogen metabolism — specifically, an excess of the more proliferative 16-alpha-hydroxyestrone metabolite relative to the protective 2-hydroxyestrone pathway.

DIM (diindolylmethane), derived from cruciferous vegetables, is the primary active compound in DIMension 3®. It supports the liver's Phase I and Phase II detoxification pathways to shift estrogen metabolism toward the protective 2-OH pathway. This has implications for breast tissue health, uterine health, prostate health, and the symptom burden associated with estrogen dominance — including weight gain around the hips and thighs, breast tenderness, mood instability, and heavy periods.

Clinical context: Dr. Wrigley recommends DIMension 3® for patients presenting with the Estrogen Dominant archetype, as well as men in the Andropause archetype where elevated estradiol relative to testosterone is identified. This product works synergistically with liver support and fiber intake to optimize estrogen clearance. Your clinician can help determine whether this is appropriate for your situation.

About Dr. Jay Wrigley, NMD
Dr. Jay Wrigley is a licensed Naturopathic Medical Doctor (NMD) and Functional Medicine practitioner with over 30 years of clinical experience specializing in hormone optimization, metabolic health, and longevity medicine. He is the creator of the LCHPMF™ (Lifestyle, Circadian, Hormonal, Psychological, Metabolic, and Functional) clinical framework — a comprehensive, root-cause approach to understanding why the body's hormone and metabolic systems shift with age, stress, and lifestyle. Dr. Wrigley's protocols are grounded in peer-reviewed research, clinical outcomes, and his proprietary 16-archetype pattern recognition system, which identifies the specific hormonal and metabolic patterns driving each patient's symptoms.

This product is available through Dr. Wrigley's professional dispensary. Use code DRWRIGLEY at Wholescripts or access his curated Fullscript dispensary at fullscript.com/welcome/drjaywrigley. These are physician-curated recommendations, not medical advice. Always consult your licensed healthcare provider before starting any supplement protocol.